This study assessed the climate change vulnerability of households in 12 municipalities in Laguna province. The vulnerability incidence was high for those employed in the commercial and services sector, and for those with agriculture-dependent livelihoods. Female-headed households were also found to have high vulnerability incidence. In terms of frequency and proportion of households affected, results further indicate that the most significant natural hazards for the province are typhoon and floods. The most widespread impacts were damage to houses, psychological and emotional distress, and loss of income. The interventions preferred were financial, livelihood and medical assistance; relief goods provision; information dissemination; and flood mitigation infrastructure.